Hepatocyte Growth Factor (HGF) Expression in High-Fat Diet Fed Rat Corpus Cavernosum. Preliminary results

Human hepatocyte growth factor (HGF) in the aqueous humor.

Using an enzyme-linked immunosorbent assay, we measured the concentration of hepatocyte growth factor (HGF) in human aqueous humor and serum from 36 eyes of 33 patients and analyzed the relationship between HGF and several parameters of corneal endothelial cells. Aqueous HGF concentrations ranged from 0.020-0.194 ng/mL (average: 0.101 +/- 0.044 ng/mL) and was correlated positively with corneal ...

Platelet-derived growth factor (PDGF) and PDGF receptors in rat corpus cavernosum: changes in expression after transient in vivo hypoxia.

Platelet-derived growth factor (PDGF) overactivity has been implicated in atherosclerosis and several fibrotic conditions including lung and kidney fibrosis, liver cirrhosis and myelofibrosis. Low oxygen tension (hypoxia) is a known stimulus for transcriptional induction of PDGF ligand and receptor genes in different tissues. We studied the expression and localization of PDGF-A, PDGF-B, and PDG...

Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet

We showed previously that UBXD8 plays a key role in proteasomal degradation of lipidated ApoB in hepatocarcinoma cell lines. In the present study, we aimed to investigate the functions of UBXD8 in liver in vivo. For this purpose, hepatocyte-specific UBXD8 knockout (UBXD8-LKO) mice were generated. They were fed with a normal or high-fat diet, and the phenotypes were compared with those of litter...

Correction: Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet

Phenotypic modulation of rat corpus cavernosum smooth muscle cells induced by platelet-derived growth factor-BB

Background: Phenotypic modulation within corpus cavernosum smooth muscle cells (CCSMCs) plays a critical role in the pathogenesis of erectile dysfunction (ED), yet little is known regarding the effects of plateletderived growth factor-BB (PDGF-BB) on CCSMCs phenotype. Objective: The aim of the present study was to evaluate the effect of PDGF-BB on phenotypic modulation of CCSMCs. Method: Cell v...